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| Combination of | |
|---|---|
| DTaP vaccine | Vaccine |
| Inactivated poliovirus vaccine | Vaccine |
| Hib vaccine | Vaccine |
| Clinical data | |
| Trade names | Pentacel, Pediacel, Infanrix IPV + Hib, others |
| AHFS/Drugs.com | FDA Professional Drug Information |
| Routes of administration | Intramuscular injection |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
DTaP-IPV/Hib vaccine is a 5-in-1 combination vaccine that protects against diphtheria, tetanus, whooping cough, polio, and Haemophilus influenzae type B.[1][2]
Its generic name is "diphtheria and tetanus toxoids and acellular pertussis adsorbed, inactivated poliovirus and haemophilus B conjugate vaccine", and it is also known as DTaP-IPV-Hib.[1]
Uses
[edit]DTaP-IPV/Hib vaccine is administered to young children to immunise against diphtheria, tetanus, pertussis, poliomyelitis, and diseases caused by Haemophilus influenzae type B.[1]
Formulations
[edit]A branded formulation marketed in the United States is Pentacel, manufactured by Sanofi Pasteur.[3]
Pentacel is known in the UK and Canada as Pediacel.[4][5]
An equivalent vaccine marketed in the UK and Canada by GlaxoSmithKline is Infanrix IPV + Hib.[5] This is a two-part vaccine. The DTaP-IPV component is supplied as a sterile liquid, which is used to reconstitute lyophilized (freeze-dried) Hib vaccine.[citation needed]
Pentaxim is a liquid formulation marketed by Sanofi Pasteur.[6]
Availability
[edit]It is only licensed for young children.[7] The United States Food and Drug Administration has approved[when?] the vaccine for children from age 6 weeks up to age 5 years.[1] It was used in the UK until 2017, following which a 6-in-1 vaccine became available containing the additional protection against Hepatitis B.[2]
References
[edit]- ^ a b c d "Diphtheria and Tetanus Toxoids, Acellular Pertussis, Poliovirus and Haemophilus b Conjugate Vaccine". Drugs.com. Retrieved 15 July 2018.
- ^ a b "5-in-1 Vaccine (also called Pentavalent Vaccine)". Vaccine Knowledge Project. 3 January 2021. Retrieved 3 July 2018.
- ^ "Pentacel". U.S. Food and Drug Administration(FDA). STN 125145. Archived from the original on 27 August 2009. Retrieved 15 July 2018.
- ^ "Pediacel syringe - Summary of Product Characteristics (SmPC)". Datapharm. 17 April 2019. Archived from the original on 17 October 2019. Retrieved 16 October 2019.
- ^ a b "Diphteria Toxoid: Canadian Immunization Guide". Public Health Agency of Canada. December 2014. Archived from the original on 24 September 2019. Retrieved 16 October 2019.
- ^ Plotkin SA, Liese J, Madhi SA, Ortiz E (July 2011). "A DTaP-IPV/PRP~T vaccine (Pentaxim): a review of 16 years' clinical experience". Expert Rev Vaccines. 10 (7): 981–1005. doi:10.1586/erv.11.72. PMID 21749196. S2CID 207224675.
- ^ "Diphtheria toxoid / haemophilus b conjugate (prp-t) vaccine / pertussis, acellular / poliovirus vaccine, inactivated / tetanus toxoid (Pentacel) Use During Pregnancy". Drugs.com. Retrieved 2 January 2021.
